蔣翔銳

蔣翔銳 

藥物化學(xué)專(zhuān)業(yè)，中國科學(xué)院上海藥物研究所研究員，碩士生導師。2006年進(jìn)入上海藥物所進(jìn)行博士后研究工作，出站后留所工作至今。作為骨干人員或主要發(fā)明人參與2個(gè)1類(lèi)創(chuàng )新藥物TPN729、TPN171的研究開(kāi)發(fā)并獲得臨床批件。負責多項國家自然科學(xué)基金面上項目、“新藥創(chuàng )制”國家重大專(zhuān)項、中科院先導專(zhuān)項和藥物創(chuàng )新研究院自主部署項目，并參與多項國家863計劃、中科院活性天然產(chǎn)物發(fā)現評價(jià)與轉化項目以及上海市科技支撐計劃等科研項目。

研究領(lǐng)域： 

小分子構效關(guān)系研究、天然產(chǎn)物結構修飾與藥物合成工藝研究。主要研究?jì)热轂橹袠猩窠?jīng)系統疾病與心腦血管疾病相關(guān)創(chuàng )新藥物發(fā)現。

代表性論文：

1、Junchi Zhang^#, Fuqiang Zhu, Guanghui Tian, Xiangrui Jiang*, Jingshan Shen, Improved Synthesis of 6-Chloro-5-methylpyridin-2-amine: A Key Intermediate for Making Lumacaftor, https://doi.org/10.1021 /acs.oprd.9b00556.

2、Zhen Wang^#, Xiangrui Jiang^#, Xianglei Zhang^#, Guanghui Tian, Rulei Yang, Jianzhong Wu, Xiaoli Zhou, Zheng Liu, Xiaojun Yang, Chunhui Wu, Jing Shi, Jianfang Li, Jin Suo, Yu Wang, Rongxia Zhang, Zhijian Xu, Xudong Gong, Yang He, Weiliang Zhu, Haji Akber Aisa, Hualiang Jiang*, Yechun Xu*, and Jingshan Shen*. Pharmacokinetic-driven optimization of 4(3H)-pyrimidiones as phosphodiesterase Type 5 inhibitiors leading to TPN171, a clinical candidate for the treatment of pulmonary arterial hypertension, Journal of Medicinal Chemistry, 2019, 62, 4979−4990

3、Jing Xing^#, Rukang Zhang^#, Xiangrui Jiang^#, Tianwen Hu, Xinjun Wang, Gang Qiao, Junjian Wang, Fengling Yang, Xiaomin Luo, Kaixian Chen, Jingshan Shen*, Cheng Luo*, Hualiang Jiang, Mingyue Zheng*, Rational Design of 5-((1H-imidazol-1-yl)methyl)quinolin-8-ol derivatives as novel bromodomain-containing protein 4 inhibitors, European Journal of Medicinal Chemistry, 2019, 163, 281−294.

4、Tianwen Hu^#, Feipu Yang, Tao Jiang, Weiming Chen, Jian Zhang, Jianfeng Li, Xiangrui Jiang*, Jingshan Shen, Synthesis of Impurities From Pramipexole Dihydrochloride Tablet, Organic Process Research & Development, 2016，20,1899−1905.

5、Chunhui Wu^#, Weiming Chen, Dehui Jiang, Xiangrui Jiang,* Jingshan Shen An Improved Synthesis of 4-(1-Piperazinyl)benzo[b]thiophene Dihydrochloride, Organic Process Research & Development, 2015, 19, 555−558

其他科研科研成果（專(zhuān)利等）：

1、一類(lèi)雜環(huán)化合物、其制備方法和用途；中國申請號：CN201580008897.5

2、一種?；被拎さ闹苽浼捌溆猛?；公開(kāi)號：CN2017101885472